trans-(3-Hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester
tert-Butyl trans-(3-hydroxymethyl)-cyclohexylcarbamate
CAS: 920966-17-2
Molecular Formula: C12H23NO3
trans-(3-Hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester - Names and Identifiers
trans-(3-Hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C12H23NO3 |
| Molar Mass | 229.32 |
| Density | 1.05±0.1 g/cm3(Predicted) |
| Boling Point | 351.6±11.0 °C(Predicted) |
| pKa | 12.48±0.40(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD03844607 |
trans-(3-Hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester - Introduction
tert-Butyl trans-(3-hydroxymethyl)-cyclohexylcarbamate, abbreviated as TBCC, is an organic compound. Its properties are as follows:
1. Appearance: TBCC is a white solid.
2. Solubility: TBCC is soluble in many organic solvents, such as alcohols, ethers and ketones. Its solubility in water is low.
The main purpose of TBCC:
1. Chemical synthesis: TBCC is a commonly used amino protection reagent, which is widely used in organic synthesis and can be used to protect the nitrogen atom of amino compounds.
2. Drug research: TBCC is used as an intermediate in drug synthesis for the synthesis of antibiotics, hormones, phospholipids and other important bioactive molecules.
Preparation of TBCC:
TBCC can be synthesized by the following steps:
1. First, the cyclohexylamine is reacted with tert-butylchloroformate to generate tert-butyl cyclohexylcarbamate.
2. Then, the tert-butyl cyclohexylcarbamate is reacted with formaldehyde to generate the tert-Butyl trans-(3-hydroxymethyl)-cyclohexylcarbamate.
Safety information for TBCC:
1. TBCC is relatively safe under routine operations, but appropriate laboratory safety measures and personal protective equipment, such as gloves and goggles, are still required.
2. TBCC may cause irritation to the skin and eyes, so direct contact should be avoided during use.
3. TBCC may burn under flame, so it is necessary to avoid high temperature and open flame.
4. Detailed information on the toxicity and ecological effects of TBCC should be further studied before use in the laboratory and operated in accordance with relevant operating guidelines.
1. Appearance: TBCC is a white solid.
2. Solubility: TBCC is soluble in many organic solvents, such as alcohols, ethers and ketones. Its solubility in water is low.
The main purpose of TBCC:
1. Chemical synthesis: TBCC is a commonly used amino protection reagent, which is widely used in organic synthesis and can be used to protect the nitrogen atom of amino compounds.
2. Drug research: TBCC is used as an intermediate in drug synthesis for the synthesis of antibiotics, hormones, phospholipids and other important bioactive molecules.
Preparation of TBCC:
TBCC can be synthesized by the following steps:
1. First, the cyclohexylamine is reacted with tert-butylchloroformate to generate tert-butyl cyclohexylcarbamate.
2. Then, the tert-butyl cyclohexylcarbamate is reacted with formaldehyde to generate the tert-Butyl trans-(3-hydroxymethyl)-cyclohexylcarbamate.
Safety information for TBCC:
1. TBCC is relatively safe under routine operations, but appropriate laboratory safety measures and personal protective equipment, such as gloves and goggles, are still required.
2. TBCC may cause irritation to the skin and eyes, so direct contact should be avoided during use.
3. TBCC may burn under flame, so it is necessary to avoid high temperature and open flame.
4. Detailed information on the toxicity and ecological effects of TBCC should be further studied before use in the laboratory and operated in accordance with relevant operating guidelines.
Last Update：2024-04-09 21:54:55
